The effect of amaranth seeds on the lipid profile, glucose level, protein metabolism and selected trace element (Na, K, Ca and Mg) levels were determined in high-fructose fed Wistar rats. Fructose addition to rat fodder caused changes mainly in the blood lipid profile, particularly manifesting in an increased triglyceride level within all subsequent pairs of rat groups, and ranged between 85% and 112%. Administration of amaranth seeds to rats did not inhibit the increase of triglyceride induced by fructose. There was an increase in glucose concentration of between 3% and 14%. Uric acid concentrations also increased in all groups (30-37%), while changes in creatinine levels were varied. Fructose addition to fodder also brought about a significant decrease in alkaline phosphatase activity (9-20%).