Novel N-chloroheterocyclic antimicrobials

Charles Francavilla; Eric D Turtle; Bum Kim; Donogh J R O'Mahony; Timothy P Shiau; Eddy Low; Nichole J Alvarez; Chris E Celeri; Louisa D'Lima; Lisa C Friedman; Francis S Ruado; Ping Xu; Meghan E Zuck; Mark B Anderson; Ramin Ron Najafi; Rakesh K Jain

doi:10.1016/j.bmcl.2011.03.035

Novel N-chloroheterocyclic antimicrobials

Bioorg Med Chem Lett. 2011 May 15;21(10):3029-33. doi: 10.1016/j.bmcl.2011.03.035. Epub 2011 Mar 16.

Authors

Charles Francavilla¹, Eric D Turtle, Bum Kim, Donogh J R O'Mahony, Timothy P Shiau, Eddy Low, Nichole J Alvarez, Chris E Celeri, Louisa D'Lima, Lisa C Friedman, Francis S Ruado, Ping Xu, Meghan E Zuck, Mark B Anderson, Ramin Ron Najafi, Rakesh K Jain

Affiliation

¹ NovaBay Pharmaceuticals Inc., 5980 Horton St. Suite 550, Emeryville, CA 94608, USA.

PMID: 21459574
DOI: 10.1016/j.bmcl.2011.03.035

Abstract

Antimicrobial compounds with broad-spectrum activity and minimal potential for antibiotic resistance are urgently needed. Toward this end, we prepared and investigated a novel series of N-chloroheterocycles. Of the compounds examined, the N-chloroamine series were found superior over N-chloroamide series in regards to exhibiting high antimicrobial activity, low cytotoxicity, and long-term aqueous stability.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Infective Agents / chemical synthesis
Anti-Infective Agents / chemistry*
Anti-Infective Agents / pharmacology*
Bacteria / drug effects*
Chlorine / chemistry
Fungi / drug effects*
Heterocyclic Compounds / chemical synthesis
Heterocyclic Compounds / chemistry*
Heterocyclic Compounds / pharmacology*
Microbial Sensitivity Tests
Molecular Structure

Substances

Anti-Infective Agents
Heterocyclic Compounds
Chlorine