Cytotoxic geranylflavonoids from Bonannia graeca

Phytochemistry. 2011 Jun;72(9):942-5. doi: 10.1016/j.phytochem.2011.03.005. Epub 2011 Apr 1.

Abstract

The analysis of the aerial parts of Bonannia graeca led to the isolation and characterization of polar geranylated flavonoids (6 and 7). The structure elucidation was performed by extensive spectroscopic methods (1D and 2D NMR) and comparison with literature data. All natural flavonoids isolated from B. graeca (1-7) and some synthetic derivatives (8-11) were tested for cytotoxic activity against four human tumor cell lines. Preliminary structure-activity relationship correlations are discussed.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Cell Line, Tumor
  • Euphorbiaceae / chemistry*
  • Flavonoids / chemistry*
  • Flavonoids / isolation & purification
  • Humans
  • Molecular Structure
  • Plant Components, Aerial / chemistry*
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents, Phytogenic
  • Flavonoids