Surface enhanced Raman scattering of neurotransmitter release in neuronal cells using antibody conjugated gold nanoparticles

J Nanosci Nanotechnol. 2011 Feb;11(2):1585-8. doi: 10.1166/jnn.2011.3410.

Abstract

This study demonstrated the potential feasibility of using antibody-conjugated gold nanoparticles as highly sensitive and homogeneous sensing probes for biological monitoring of neurotransmitters in neuronal cells. Bands at 1152 and 1322 cm(-1) were also similar to SERS of metal catecholates, and could be assigned to catechol ring vibration and carbon-oxygen stretches.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Immobilized*
  • Cell Line
  • Dopamine / analysis
  • Dopamine / immunology*
  • Dopamine / metabolism*
  • Gold
  • Humans
  • Metal Nanoparticles* / ultrastructure
  • Microscopy, Electron, Scanning
  • Nanotechnology
  • Neurons / metabolism*
  • Spectrum Analysis, Raman

Substances

  • Antibodies, Immobilized
  • Gold
  • Dopamine