Desmoplastic small cell tumor with bizarre giant nuclei

Int J Surg Pathol. 2011 Dec;19(6):843-6. doi: 10.1177/1066896911400738. Epub 2011 Mar 31.

Abstract

A case is reported of an intra-abdominal desmoplastic small cell tumor featuring giant bizarre nuclei, an event not previously recorded in this entity to the best of the authors' knowledge. The diagnosis was confirmed by immunohistochemistry and molecular genetics. A list is provided of the many other conditions in which this morphologically spectacular but clinically inconsequential nuclear change has been recorded.

Publication types

  • Case Reports

MeSH terms

  • Abdominal Neoplasms / diagnosis*
  • Abdominal Neoplasms / genetics
  • Abdominal Neoplasms / metabolism
  • Adult
  • Biomarkers, Tumor / metabolism
  • Cell Nucleus / pathology*
  • DNA, Neoplasm / analysis
  • Desmoplastic Small Round Cell Tumor / diagnosis*
  • Desmoplastic Small Round Cell Tumor / genetics
  • Desmoplastic Small Round Cell Tumor / metabolism
  • Humans
  • Male
  • Oncogene Proteins, Fusion / genetics
  • Oncogene Proteins, Fusion / metabolism
  • Translocation, Genetic / genetics

Substances

  • Biomarkers, Tumor
  • DNA, Neoplasm
  • EWS1-WT1 fusion protein, human
  • Oncogene Proteins, Fusion