Abstract
A case is reported of an intra-abdominal desmoplastic small cell tumor featuring giant bizarre nuclei, an event not previously recorded in this entity to the best of the authors' knowledge. The diagnosis was confirmed by immunohistochemistry and molecular genetics. A list is provided of the many other conditions in which this morphologically spectacular but clinically inconsequential nuclear change has been recorded.
MeSH terms
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Abdominal Neoplasms / diagnosis*
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Abdominal Neoplasms / genetics
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Abdominal Neoplasms / metabolism
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Adult
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Biomarkers, Tumor / metabolism
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Cell Nucleus / pathology*
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DNA, Neoplasm / analysis
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Desmoplastic Small Round Cell Tumor / diagnosis*
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Desmoplastic Small Round Cell Tumor / genetics
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Desmoplastic Small Round Cell Tumor / metabolism
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Humans
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Male
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Oncogene Proteins, Fusion / genetics
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Oncogene Proteins, Fusion / metabolism
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Translocation, Genetic / genetics
Substances
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Biomarkers, Tumor
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DNA, Neoplasm
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EWS1-WT1 fusion protein, human
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Oncogene Proteins, Fusion