Rational design of a Tn antigen mimic

Chem Commun (Camb). 2011 May 14;47(18):5319-21. doi: 10.1039/c1cc10192g. Epub 2011 Mar 31.

Abstract

A novel Tn antigen mimic, in which the natural underlying amino acid has been replaced by the non-natural α-methylserine analogue, is reported. This derivative exhibits a similar affinity for a natural lectin as for the natural Tn and retains the bioactive conformation observed in the Tn-containing glycopeptides with anti-MUC1 antibodies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Tumor-Associated, Carbohydrate / chemistry*
  • Antigens, Tumor-Associated, Carbohydrate / immunology*
  • Glycopeptides / chemistry
  • Glycopeptides / metabolism
  • Lectins / chemistry
  • Lectins / metabolism
  • Mice
  • Molecular Sequence Data
  • Molecular Structure
  • Mucin-1 / chemistry*
  • Serine / analogs & derivatives*
  • Serine / chemistry

Substances

  • Antigens, Tumor-Associated, Carbohydrate
  • Glycopeptides
  • Lectins
  • Mucin-1
  • Tn antigen
  • 2-methylserine
  • Serine