Abstract
A novel Tn antigen mimic, in which the natural underlying amino acid has been replaced by the non-natural α-methylserine analogue, is reported. This derivative exhibits a similar affinity for a natural lectin as for the natural Tn and retains the bioactive conformation observed in the Tn-containing glycopeptides with anti-MUC1 antibodies.
© The Royal Society of Chemistry 2011
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, Tumor-Associated, Carbohydrate / chemistry*
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Antigens, Tumor-Associated, Carbohydrate / immunology*
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Glycopeptides / chemistry
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Glycopeptides / metabolism
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Lectins / chemistry
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Lectins / metabolism
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Mice
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Molecular Sequence Data
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Molecular Structure
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Mucin-1 / chemistry*
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Serine / analogs & derivatives*
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Serine / chemistry
Substances
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Antigens, Tumor-Associated, Carbohydrate
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Glycopeptides
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Lectins
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Mucin-1
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Tn antigen
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2-methylserine
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Serine