Abstract
Mycobacterium smegmatis is a species of rapidly growing saprophytes with a number of properties that make it an effective vaccine vector. Recombinant M. smegmatis expressing protective antigens of different pathogens and molecules modulating the immune responses offers some potential for reduction of the burden of tuberculosis, HIV and hepatitis B infections. This paper discusses the molecular methods used to generate recombinant M. smegmatis and the results obtained with some of these recombinants.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, Bacterial / biosynthesis
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Antigens, Bacterial / genetics
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Antigens, Bacterial / immunology
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HIV Antigens / biosynthesis
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HIV Antigens / genetics
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HIV Antigens / immunology
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Humans
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Mycobacterium smegmatis / genetics*
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Mycobacterium smegmatis / immunology*
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Transformation, Bacterial / genetics*
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Transformation, Bacterial / immunology*
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Vaccines, Synthetic / genetics*
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Vaccines, Synthetic / immunology*
Substances
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Antigens, Bacterial
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HIV Antigens
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Vaccines, Synthetic