Determination of serotonin on a glassy carbon electrode modified by electropolymerization of meso-tetrakis(2-aminophenyl)porphyrin and single walled carbon nanotubes

J Nanosci Nanotechnol. 2011 Mar;11(3):2407-12. doi: 10.1166/jnn.2011.3523.

Abstract

A chemically modified electrode [poly(TAPP)-SWNT/GCE] was prepared by electropolymerization of meso-tetrakis(2-aminophenyl)porphyrin (TAPP)-single walled carbon nanotubes (SWNT) on the surface of a glassy carbon electrode (GCE). This modified electrode was employed as an electrochemical biosensor for the determination of serotonin concentration and exhibited a typical enhance effect on the current response of serotonin and lower oxidation overpotential. The biosensor was very effective to determined 5-HT in a mixture. The linear response was in the range 2.0 x 10(-7) to 1.0 x 10(-5) M, with a correlation coefficient of 0.999 [i(p)(microA) = 3.406 C (microM)+0.132] on the anodic current, with a detection limit of 1 x 10(-9) M. Due to the relatively low currents and different potentials in the electrochemical responses to ascorbic acid and dopamine, the modified electrode is a useful and effective sensing device for the selective and sensitive serotonin determination in the presence of ascorbic acid and dopamine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Complex Mixtures / analysis
  • Conductometry / instrumentation*
  • Crystallization / methods
  • Electrodes*
  • Electroplating / methods
  • Equipment Design
  • Equipment Failure Analysis
  • Glass / chemistry
  • Nanotechnology / instrumentation*
  • Nanotubes, Carbon / chemistry*
  • Nanotubes, Carbon / ultrastructure
  • Particle Size
  • Porphyrins / chemistry*
  • Serotonin / analysis*

Substances

  • Complex Mixtures
  • Nanotubes, Carbon
  • Porphyrins
  • Serotonin