Direct displacement of alkoxy groups of vinylogous esters by Grignard reagents

J Org Chem. 2011 May 6;76(9):3515-8. doi: 10.1021/jo102537n. Epub 2011 Mar 29.

Abstract

The direct displacement of alkoxy groups from the β position of aromatic and unsaturated esters and ketones is described. The reaction is chemo- and regioselective, displaying wide substrate scope.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Electrons*
  • Esters
  • Hydrocarbons, Aromatic / chemistry*
  • Indicators and Reagents / chemistry
  • Ketones / chemistry*
  • Models, Molecular
  • Molecular Conformation

Substances

  • Esters
  • Hydrocarbons, Aromatic
  • Indicators and Reagents
  • Ketones