Briarane diterpenes diminish COX-2 expression in human colon adenocarcinoma cells

P Matthew Joyner; Amanda L Waters; Russell B Williams; Douglas R Powell; Naveena B Janakiram; Chinthalapally V Rao; Robert H Cichewicz

doi:10.1021/np100775a

Briarane diterpenes diminish COX-2 expression in human colon adenocarcinoma cells

J Nat Prod. 2011 Apr 25;74(4):857-61. doi: 10.1021/np100775a. Epub 2011 Mar 25.

Authors

P Matthew Joyner¹, Amanda L Waters, Russell B Williams, Douglas R Powell, Naveena B Janakiram, Chinthalapally V Rao, Robert H Cichewicz

Affiliation

¹ Natural Products Discovery Group, Department of Chemistry and Biochemistry, Stephenson Life Sciences Research Center, 101 Stephenson Parkway, University of Oklahoma, Norman, Oklahoma 73019, USA.

PMID: 21438584
DOI: 10.1021/np100775a

Abstract

Exploration of a soft coral (Briareum sp.) from Vanuatu led to the isolation of three new briaranes, designated brialalepolides A (1), B (2), and C (3). Compounds 2 and 3 reduced the expression of COX-2 in human colon adenocarcinoma cells, as well as in murine macrophage cells. This is significant because the metabolic products of COX-2 have been implicated in the pathogenesis of colon cancer and other diseases.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Anthozoa / chemistry*
Base Sequence
Colonic Neoplasms
Cyclooxygenase 2 Inhibitors / chemistry
Cyclooxygenase 2 Inhibitors / isolation & purification*
Cyclooxygenase 2 Inhibitors / pharmacology*
Diterpenes / chemistry
Diterpenes / isolation & purification*
Diterpenes / pharmacology*
Humans
Mice
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular

Substances

Cyclooxygenase 2 Inhibitors
Diterpenes
brialalepolide A
brialalepolide B
brialalepolide C