Reducing the cost, smell, and toxicity of the Barton reductive decarboxylation: chloroform as the hydrogen atom source

Eun Jung Ko; G Paul Savage; Craig M Williams; John Tsanaktsidis

doi:10.1021/ol200290m

Reducing the cost, smell, and toxicity of the Barton reductive decarboxylation: chloroform as the hydrogen atom source

Org Lett. 2011 Apr 15;13(8):1944-7. doi: 10.1021/ol200290m. Epub 2011 Mar 25.

Authors

Eun Jung Ko¹, G Paul Savage, Craig M Williams, John Tsanaktsidis

Affiliation

¹ School of Chemistry and Molecular Biosciences, University of Queensland, Brisbane 4072, Queensland, Australia.

PMID: 21438514
DOI: 10.1021/ol200290m

Abstract

When used as solvent, chloroform was found to act as a hydrogen atom donor in Barton reductive decarboxylation reactions. Chloroform offers a substantial practical advantage over pre-existing hydrogen atom donors.