The chelation targeting metal-Aβ40 aggregates may lead to formation of Aβ40 oligomers

Dalton Trans. 2011 May 14;40(18):4830-3. doi: 10.1039/c1dt00020a. Epub 2011 Mar 24.

Abstract

The fluorescent chelator (FC-1) was designed by combining a metal-chelating unit and a ThT-based Aβ aggregate-binding fluorescent unit. FC-1 is a cell membrane-penetrable chelator with a moderate chelation ability to Cu(2+) and Zn(2+) and can target metal-Aβ40 aggregates. Treatment with FC-1 led to enhanced cytotoxicity of the aggregates, because the aggregates were converted into a pool of oligomers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid beta-Peptides / chemistry*
  • Amyloid beta-Peptides / metabolism
  • Chelating Agents / chemistry*
  • Coordination Complexes / chemistry
  • Coordination Complexes / toxicity
  • Copper / chemistry
  • HeLa Cells
  • Humans
  • Hydrogen-Ion Concentration
  • Metals / chemistry*
  • Molecular Conformation
  • Peptide Fragments / chemistry*
  • Peptide Fragments / metabolism
  • Zinc / chemistry

Substances

  • Amyloid beta-Peptides
  • Chelating Agents
  • Coordination Complexes
  • Metals
  • Peptide Fragments
  • amyloid beta-protein (1-40)
  • Copper
  • Zinc