Rapid carbonylative coupling reactions using palladium(I) dimers: applications to 11CO-radiolabelling for the synthesis of PET tracers

Gabriella Buscemi; Philip W Miller; Steven Kealey; Antony D Gee; Nicholas J Long; Jan Passchier; Ramon Vilar

doi:10.1039/c1ob05268c

Rapid carbonylative coupling reactions using palladium(I) dimers: applications to 11CO-radiolabelling for the synthesis of PET tracers

Org Biomol Chem. 2011 May 7;9(9):3499-503. doi: 10.1039/c1ob05268c. Epub 2011 Mar 24.

Authors

Gabriella Buscemi¹, Philip W Miller, Steven Kealey, Antony D Gee, Nicholas J Long, Jan Passchier, Ramon Vilar

Affiliation

¹ Department of Chemistry, Imperial College London, South Kensington, London, UK SW7 2AZ.

PMID: 21431235
DOI: 10.1039/c1ob05268c

Abstract

Palladium dimers with sterically hindered phosphines have been shown to be excellent pre-catalysts for the aminocarbonylation of aryl halides to yield amides and one of them has been successfully employed as a pre-catalyst for the synthesis of (11)C-radiolabelled amides for PET imaging.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amides / chemical synthesis*
Carbon Monoxide / chemistry*
Carbon Radioisotopes / chemistry
Catalysis
Cross-Linking Reagents / chemistry
Dimerization
Molecular Structure
Palladium / chemistry*
Positron-Emission Tomography
Time Factors

Substances

Amides
Carbon Radioisotopes
Cross-Linking Reagents
Palladium
Carbon Monoxide