Abstract
Three new limonoids, chisomicines A-C (1-3), have been isolated from the bark of Chisocheton ceramicus. Their structures were determined by 2D NMR, CD spectroscopic methods, and X-ray analysis. Chisomicine A (1) exhibited NO production inhibitory activity in J774.1 cells stimulated by LPS dose-dependently at high cell viability.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Crystallography, X-Ray
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Dose-Response Relationship, Drug
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Limonins / chemistry
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Limonins / isolation & purification*
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Limonins / pharmacology
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Lipopolysaccharides / pharmacology
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Malaysia
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Meliaceae / chemistry*
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Mice
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Models, Molecular
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Molecular Structure
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Nitric Oxide / antagonists & inhibitors
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Nuclear Magnetic Resonance, Biomolecular
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Plant Bark / chemistry
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omega-N-Methylarginine / pharmacology
Substances
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Limonins
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Lipopolysaccharides
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chisomicine A
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chisomicine B
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chisomicine C
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omega-N-Methylarginine
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Nitric Oxide