Synthesis and in vitro insulin-mimetic activities of zinc(ii) complexes of ethyl 2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxylates

Hikaru Kawarada; Yutaka Yoshikawa; Hiroyuki Yasui; Shunsuke Kuwahara; Yoichi Habata; Ryota Saito

doi:10.1039/c1mt00009h

Synthesis and in vitro insulin-mimetic activities of zinc(ii) complexes of ethyl 2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxylates

Metallomics. 2011 Jul;3(7):675-9. doi: 10.1039/c1mt00009h. Epub 2011 Mar 18.

Authors

Hikaru Kawarada¹, Yutaka Yoshikawa, Hiroyuki Yasui, Shunsuke Kuwahara, Yoichi Habata, Ryota Saito

Affiliation

¹ Department of Chemistry, Toho University, 2-2-1 Miyama, Funabashi, Chiba, Japan.

PMID: 21423934
DOI: 10.1039/c1mt00009h

Abstract

Several Zn(II) complexes (2a-e) of 1-arylmethyl-2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxylates (1a-e), known drug candidates for diabetic complications, were synthesized and proved to have in vitro insulin-mimetic activities, suggesting that these complexes are potential chemotherapeutics that are effective against both diabetes and diabetic complications.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adipocytes / drug effects
Adipocytes / metabolism
Animals
Crystallography, X-Ray
Epinephrine / pharmacology
Fatty Acids / metabolism
Inhibitory Concentration 50
Insulin / analogs & derivatives*
Molecular Conformation
Pyrroles / chemical synthesis*
Pyrroles / chemistry
Pyrroles / pharmacology*
Rats
Zinc / chemistry
Zinc / pharmacology*

Substances

Fatty Acids
Insulin
Pyrroles
Zinc
Epinephrine