Synthesis, characterization and biological properties of cobalt(II) complexes of 1,10-phenanthroline and maltol

J Inorg Biochem. 2011 Mar;105(3):339-47. doi: 10.1016/j.jinorgbio.2010.11.018. Epub 2010 Dec 7.

Abstract

The synthesis and characterization of two cobalt(II) complexes, Co(phen)(ma)Cl 1 and Co(ma)(2)(phen) 2, (phen=1,10-phenanthroline, ma(-)=maltolate or 2-methyl-4-oxo-4H-pyran-3-olate) are reported herein. The complexes have been characterized by FTIR, CHN analysis, fluorescence spectroscopy, UV-visible spectroscopy, conductivity measurement and X-ray crystallography. The number of chelated maltolate ligands seems to influence their DNA recognition, topoisomerase I inhibition and antiproliferative properties.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Breast Neoplasms / metabolism
  • Breast Neoplasms / pathology
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Chelating Agents / chemical synthesis
  • Chelating Agents / chemistry
  • Chelating Agents / pharmacology
  • Cobalt / chemistry*
  • Crystallography, X-Ray
  • DNA / chemistry
  • DNA / metabolism
  • DNA Topoisomerases, Type I / metabolism
  • Female
  • Humans
  • Inhibitory Concentration 50
  • Ligands
  • Organometallic Compounds / chemical synthesis*
  • Organometallic Compounds / chemistry
  • Organometallic Compounds / pharmacology*
  • Phenanthrolines / chemistry*
  • Pyrones / chemistry*
  • Spectrum Analysis

Substances

  • Antineoplastic Agents
  • Chelating Agents
  • Ligands
  • Organometallic Compounds
  • Phenanthrolines
  • Pyrones
  • maltol
  • Cobalt
  • DNA
  • DNA Topoisomerases, Type I
  • 1,10-phenanthroline