Abstract
The synthesis and characterization of two cobalt(II) complexes, Co(phen)(ma)Cl 1 and Co(ma)(2)(phen) 2, (phen=1,10-phenanthroline, ma(-)=maltolate or 2-methyl-4-oxo-4H-pyran-3-olate) are reported herein. The complexes have been characterized by FTIR, CHN analysis, fluorescence spectroscopy, UV-visible spectroscopy, conductivity measurement and X-ray crystallography. The number of chelated maltolate ligands seems to influence their DNA recognition, topoisomerase I inhibition and antiproliferative properties.
Copyright © 2010 Elsevier Inc. All rights reserved.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Antineoplastic Agents / chemical synthesis
-
Antineoplastic Agents / chemistry
-
Antineoplastic Agents / pharmacology
-
Breast Neoplasms / metabolism
-
Breast Neoplasms / pathology
-
Cell Line, Tumor
-
Cell Survival / drug effects
-
Chelating Agents / chemical synthesis
-
Chelating Agents / chemistry
-
Chelating Agents / pharmacology
-
Cobalt / chemistry*
-
Crystallography, X-Ray
-
DNA / chemistry
-
DNA / metabolism
-
DNA Topoisomerases, Type I / metabolism
-
Female
-
Humans
-
Inhibitory Concentration 50
-
Ligands
-
Organometallic Compounds / chemical synthesis*
-
Organometallic Compounds / chemistry
-
Organometallic Compounds / pharmacology*
-
Phenanthrolines / chemistry*
-
Pyrones / chemistry*
-
Spectrum Analysis
Substances
-
Antineoplastic Agents
-
Chelating Agents
-
Ligands
-
Organometallic Compounds
-
Phenanthrolines
-
Pyrones
-
maltol
-
Cobalt
-
DNA
-
DNA Topoisomerases, Type I
-
1,10-phenanthroline