MicroRNA biomarkers in lung cancer: MiRacle or quagMiRe?

Transl Res. 2011 Apr;157(4):209-15. doi: 10.1016/j.trsl.2010.12.015. Epub 2011 Jan 27.

Abstract

MicroRNAs have emerged as novel and important regulators of translation. Besides their biological significance, they are being investigated as potential biomarkers of physiological and pathological states. This review article summarizes current investigations of microRNAs as biomarkers in lung cancer. The promises and pitfalls of this exciting new investigational avenue are highlighted.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Biomarkers, Tumor / genetics*
  • Early Detection of Cancer
  • Humans
  • Lung Neoplasms / genetics*
  • Lung Neoplasms / pathology
  • MicroRNAs / analysis*
  • Microarray Analysis
  • Nutrition Assessment
  • Reverse Transcriptase Polymerase Chain Reaction

Substances

  • Biomarkers, Tumor
  • MicroRNAs