Abstract
Surfactant-free gelatin/heptamolybdate (HM) hybrid nanoparticles are prepared by a simple and environmentally friendly approach utilizing the electrostatic interaction between anionic HM and the zwitterionic gelatin. The obtained nanoparticles have a tunable size and very high HM loading content up to about 70%. In vitro and in vivo experiments prove that the gelatin/HM hybrid nanoparticles exhibit significantly better antitumor activity than plain ammonium heptamolybdate solution. Therefore, the gelatin/HM hybrid nanoparticles reported here may serve as a prototype platform for polymer/polyoxometalate (POM) hybrid nanoparticles as cancer treatment agents and hence open up more opportunities to maximize the potential of POM-based pharmaceutical agents.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line, Tumor
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Cell Proliferation / drug effects*
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Cell Survival / drug effects
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Drug Carriers / chemical synthesis*
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Drug Carriers / pharmacology
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Gelatin / chemistry*
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Gelatin / metabolism
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Humans
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Hydrogen-Ion Concentration
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Injections, Subcutaneous
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Liver Neoplasms, Experimental / drug therapy*
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Liver Neoplasms, Experimental / pathology
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Mice
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Mice, Inbred ICR
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Microscopy, Electron, Transmission
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Molybdenum / chemistry
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Molybdenum / pharmacology*
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Nanoparticles / chemistry
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Particle Size
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Spectroscopy, Fourier Transform Infrared
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Stomach Neoplasms / drug therapy*
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Stomach Neoplasms / pathology
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Tungsten Compounds / chemical synthesis*
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Tungsten Compounds / pharmacology
Substances
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Drug Carriers
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Tungsten Compounds
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polyoxometalate I
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Molybdenum
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Gelatin
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ammonium molybdate