Targeted antimicrobial moieties (WO2010080819): patent evaluation

Expert Opin Ther Pat. 2011 Apr;21(4):593-600. doi: 10.1517/13543776.2011.560571. Epub 2011 Feb 26.

Abstract

The verification of refined variants of already existing medicines proved to be a breakthrough for antibiotic research. However, resistance to old and newer antibiotics among microbacillary pathogens is evolving quickly. Drug-resistant pathogens have become an important economic burden for patients. This invention (WO2010080819) provides novel targeting moieties (peptides) that specifically/preferentially bind to microorganisms. The targeting moieties can be attached to effectors to form chimeric constructs for specifically/preferentially delivering the effector to and/or into the target organism. In certain embodiments, novel antimicrobial peptides that can be used to inhibit of certain microorganisms are provided.

MeSH terms

  • Amino Acid Sequence
  • Anti-Infective Agents / chemical synthesis
  • Anti-Infective Agents / chemistry
  • Anti-Infective Agents / pharmacology*
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Patents as Topic*
  • Peptides / chemical synthesis
  • Peptides / chemistry
  • Peptides / pharmacology*

Substances

  • Anti-Infective Agents
  • Peptides