Essential ingredients for HIV-1 budding

Winfried Weissenhorn; Heinrich Göttlinger

doi:10.1016/j.chom.2011.03.005

Essential ingredients for HIV-1 budding

Cell Host Microbe. 2011 Mar 17;9(3):172-174. doi: 10.1016/j.chom.2011.03.005.

Authors

Winfried Weissenhorn¹, Heinrich Göttlinger²

Affiliations

¹ UVHCI UMI 3265 University Joseph Fourier-EMBL-CNRS, 6 rue Jules Horowitz, 38042 Grenoble, France. Electronic address: weissenhorn@embl.fr.
² Program in Gene Function and Expression, Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: heinrich.gottlinger@umassmed.edu.

PMID: 21402355
DOI: 10.1016/j.chom.2011.03.005

Abstract

HIV-1 engages the cellular ESCRT-III/VPS4 membrane scission machinery for its escape from host cells. Three papers now begin to demystify its mode of action by showing that HIV-1 requires only the transient recruitment of a surprisingly small subset of ESCRT-III components, whose membrane abscission function depends on VPS4 activity.

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