Homoflavonoid glucosides from Ophioglossum pedunculosum and their anti-HBV activity

J Nat Prod. 2011 Apr 25;74(4):683-9. doi: 10.1021/np100745z. Epub 2011 Mar 14.

Abstract

Chemical investigation of the ethanolic extracts of the whole plant of Ophioglossum pedunculosum afforded seven new homoflavonoid glucosides, pedunculosumosides A-G (1-7). Pedunculosumosides A and C exhibit modest activity of blocking HBsAg secretion with IC(50) values of 238.0 and 70.5 μM, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / chemistry
  • Antiviral Agents / isolation & purification*
  • Antiviral Agents / pharmacology*
  • Drugs, Chinese Herbal / chemistry
  • Drugs, Chinese Herbal / isolation & purification*
  • Drugs, Chinese Herbal / pharmacology*
  • Ferns / chemistry*
  • Flavonoids / chemistry
  • Flavonoids / isolation & purification*
  • Flavonoids / pharmacology*
  • Glucosides / chemistry
  • Glucosides / isolation & purification*
  • Glucosides / pharmacology*
  • Hep G2 Cells
  • Hepatitis B Surface Antigens / drug effects
  • Hepatitis B Surface Antigens / metabolism
  • Hepatitis B virus / drug effects*
  • Humans
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular

Substances

  • Antiviral Agents
  • Drugs, Chinese Herbal
  • Flavonoids
  • Glucosides
  • Hepatitis B Surface Antigens
  • pedunculosumoside A
  • pedunculosumoside C