Abstract
Chemical investigation of the ethanolic extracts of the whole plant of Ophioglossum pedunculosum afforded seven new homoflavonoid glucosides, pedunculosumosides A-G (1-7). Pedunculosumosides A and C exhibit modest activity of blocking HBsAg secretion with IC(50) values of 238.0 and 70.5 μM, respectively.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antiviral Agents / chemistry
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Antiviral Agents / isolation & purification*
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Antiviral Agents / pharmacology*
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology*
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Ferns / chemistry*
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Flavonoids / chemistry
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Flavonoids / isolation & purification*
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Flavonoids / pharmacology*
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology*
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Hep G2 Cells
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Hepatitis B Surface Antigens / drug effects
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Hepatitis B Surface Antigens / metabolism
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Hepatitis B virus / drug effects*
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Humans
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
Substances
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Antiviral Agents
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Drugs, Chinese Herbal
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Flavonoids
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Glucosides
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Hepatitis B Surface Antigens
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pedunculosumoside A
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pedunculosumoside C