Abstract
Novel squalene synthase inhibitors are disclosed. SAR and pharmacological profile of selected compounds are discussed.
Copyright © 2011 Elsevier Ltd. All rights reserved.
MeSH terms
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Animals
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Benzazepines / chemical synthesis
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Benzazepines / chemistry*
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Benzazepines / pharmacokinetics
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Crystallography, X-Ray
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Enzyme Inhibitors / chemical synthesis
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Enzyme Inhibitors / chemistry*
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Enzyme Inhibitors / pharmacokinetics
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Farnesyl-Diphosphate Farnesyltransferase / antagonists & inhibitors*
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Farnesyl-Diphosphate Farnesyltransferase / metabolism
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Humans
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Mice
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Microsomes, Liver / metabolism
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Molecular Conformation
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Stereoisomerism
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Structure-Activity Relationship
Substances
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Benzazepines
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Enzyme Inhibitors
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Farnesyl-Diphosphate Farnesyltransferase