Abstract
Five new compounds, 9-O-angeloyl-8,10-dehydrothymol (1), 9-(3-methylbutanoyl)-8,10-dehydrothymol (2), eupatobenzofuran (3), 2-hydroxy-2,6-dimethylbenzofuran-3(2H)-one (4), and 1-(2-hydroxy-4-methylphenyl)propan-1,2-dione (5), have been isolated from the aerial part of Eupatorium cannabinum subsp. asiaticum, together with 16 known compounds (6-21). Compounds 6-8, 11, 13, and 15 exhibited inhibition (IC50 values≤18.4 μM) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 2, 3, 10, 13, and 15 inhibited fMLP/CB-induced elastase release with IC50 values≤18.3 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / isolation & purification*
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Anti-Inflammatory Agents / pharmacology*
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Benzofurans / chemistry
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Benzofurans / isolation & purification*
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Benzofurans / pharmacology*
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Eupatorium / chemistry*
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Humans
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Inhibitory Concentration 50
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Molecular Structure
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N-Formylmethionine Leucyl-Phenylalanine / metabolism
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Neutrophils / enzymology
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Pancreatic Elastase / antagonists & inhibitors
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Phenylpropionates / chemistry
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Phenylpropionates / isolation & purification*
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Phenylpropionates / pharmacology*
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Superoxides / antagonists & inhibitors
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Taiwan
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Thymol / analogs & derivatives
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Thymol / chemistry
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Thymol / isolation & purification*
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Thymol / pharmacology*
Substances
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Anti-Inflammatory Agents
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Benzofurans
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Phenylpropionates
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Superoxides
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Thymol
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N-Formylmethionine Leucyl-Phenylalanine
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Pancreatic Elastase