Matrix metalloproteinase8 has a central role in inflammatory disorders and cancer progression

Eline Dejonckheere; Roosmarijn E Vandenbroucke; Claude Libert

doi:10.1016/j.cytogfr.2011.02.002

Matrix metalloproteinase8 has a central role in inflammatory disorders and cancer progression

Cytokine Growth Factor Rev. 2011 Apr;22(2):73-81. doi: 10.1016/j.cytogfr.2011.02.002. Epub 2011 Mar 8.

Authors

Eline Dejonckheere¹, Roosmarijn E Vandenbroucke, Claude Libert

Affiliation

¹ Department for Molecular Biomedical Research, VIB, Ghent, Belgium.

PMID: 21388856
DOI: 10.1016/j.cytogfr.2011.02.002

Abstract

The predominant role of matrix metalloproteinase 8 in extracellular matrix turnover, modulation of inflammatory responses and other physiological processes is well documented. Several recent studies highlight the involvement of MMP8 in a wide range of pathologies. This review will shed light on the putative role of MMP8 as a drug target or disease marker in some inflammatory disorders and in cancer progression.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Arthritis, Rheumatoid / physiopathology
Biomarkers / metabolism
Cardiovascular Diseases / physiopathology*
Diabetic Nephropathies / physiopathology
Disease Progression
Extracellular Matrix / physiology
Eye Diseases / physiopathology
Gastrointestinal Diseases / physiopathology
Humans
Inflammation / physiopathology*
Liver Diseases / physiopathology
Lung Diseases, Obstructive / physiopathology
Malaria / physiopathology
Matrix Metalloproteinase 8 / physiology*
Neoplasms / pathology*
Nervous System Diseases / physiopathology
Periodontal Diseases / physiopathology

Substances

Biomarkers
Matrix Metalloproteinase 8