The MTHFD1L gene rs11754661 marker is not associated with Alzheimer's disease in a sample of the Spanish population

J Alzheimers Dis. 2011;25(1):47-50. doi: 10.3233/JAD-2011-101983.

Abstract

The MTHFD1L gene SNP variant rs11754661 was found to increase the risk of Alzheimer's disease in a recent Whole Genome Association Study. We have carried out an independent study of this genetic variant in 2467 individuals from Spain. We found no evidence of association between the MTHFD1L marker and susceptibility to Alzheimer's disease in our sample.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease / epidemiology*
  • Alzheimer Disease / genetics*
  • Aminohydrolases / genetics*
  • Case-Control Studies
  • Female
  • Formate-Tetrahydrofolate Ligase / genetics*
  • Genetic Markers / genetics
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study / methods*
  • Humans
  • Male
  • Methylenetetrahydrofolate Dehydrogenase (NADP) / genetics*
  • Multienzyme Complexes / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • Population Surveillance* / methods
  • Spain / epidemiology

Substances

  • Genetic Markers
  • Multienzyme Complexes
  • formyl-methenyl-methylenetetrahydrofolate synthetase
  • Methylenetetrahydrofolate Dehydrogenase (NADP)
  • Aminohydrolases
  • Formate-Tetrahydrofolate Ligase