Acute lymphoblastic leukemia with hyperleukocytosis, sinus pauses, and hypoxemic respiratory failure in an infant

Pediatr Emerg Care. 2011 Mar;27(3):212-4. doi: 10.1097/PEC.0b013e31820d8de9.

Abstract

A 5-month-old female infant presented with new-onset acute lymphoblastic leukemia and hyperleukocytosis with white blood cell count of 352 × 10(9) cells/L. She developed sinus pauses and hypoxemic respiratory failure. A manual single volume exchange blood transfusion was done with complete resolution of sinus pauses and hypoxemia.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Autonomic Nervous System Diseases / complications*
  • Autonomic Nervous System Diseases / physiopathology
  • Autonomic Nervous System Diseases / therapy
  • Electrocardiography
  • Exchange Transfusion, Whole Blood / methods*
  • Female
  • Follow-Up Studies
  • Humans
  • Hypoxia / blood
  • Hypoxia / complications*
  • Hypoxia / therapy
  • Infant
  • Leukocyte Count
  • Leukocytosis / blood
  • Leukocytosis / complications*
  • Leukocytosis / therapy
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / blood
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / therapy
  • Respiratory Insufficiency
  • Sinus Arrest, Cardiac / etiology*
  • Sinus Arrest, Cardiac / physiopathology
  • Sinus Arrest, Cardiac / therapy

Substances

  • Antineoplastic Agents