Helicobacter pylori-related gastric cancer is a special-type gastric cancer determined by genetic, environmental, and life style factors. A series of single nucleotide polymorphisms (SNPs) of susceptibility genes, including inflammation-related genes, gastric acid inhibition-related genes, and immune response-related genes, could be specifically involved in the development of Helicobacter pylori-related gastric cancer that consists of three major stages: Helicobacter pylori infection, gastric atrophy development, and carcinogenesis. The aim of the present paper was to review and evaluate the most recently published evidence on the contribution of SNPs to the carcinogenesis of Helicobacter pylori-related gastric cancer in humans.