N5-acetyl-N5-hydroxy-L-ornithine-derived siderophore-carbacephalosporin beta-lactam conjugates: iron transport mediated drug delivery

J Med Chem. 1990 Feb;33(2):461-4. doi: 10.1021/jm00164a001.

Authors

E K Dolence¹, A A Minnick, M J Miller

Affiliation

¹ Department of Chemistry, University of Notre Dame, Indiana 46556.

PMID: 2137180
DOI: 10.1021/jm00164a001

No abstract available

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Biological Transport
Cephalosporins* / chemical synthesis
Cephalosporins* / pharmacology
Chemical Phenomena
Chemistry
Escherichia coli / drug effects
Iron / metabolism*
Iron Chelating Agents* / chemical synthesis
Iron Chelating Agents* / pharmacology
Ornithine / analogs & derivatives*
Siderophores
Structure-Activity Relationship

Substances

Cephalosporins
Iron Chelating Agents
Siderophores
carbacephems
Iron
Ornithine