Anticancer activity of the PR domain of tumor suppressor RIZ1

Int J Med Sci. 2011 Feb 21;8(2):161-7. doi: 10.7150/ijms.8.161.

Abstract

Human tumor suppressor gene RIZ encodes two protein products, tumor suppressor RIZ1 and proto-oncoprotein RIZ2, which regulate cellular functions in a Yin-Yang fashion. The only structural difference between them is that RIZ2 lacks the N-terminal PR domain. In this study, we showed that RIZ1 mRNA expression level was elevated in stage IV of eight different types of cancer (stage III for prostate cancer), indicating that RIZ1 might play an important role in tumor metastasis, and the PR domain alone possessed anticancer activity.

Keywords: Human tumor suppressor; RIZ; RIZ1; tumor metastasis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cloning, Molecular
  • DNA-Binding Proteins / chemistry*
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / pharmacology*
  • DNA-Binding Proteins / physiology
  • Female
  • Gene Expression Regulation, Neoplastic
  • Histone-Lysine N-Methyltransferase / chemistry*
  • Histone-Lysine N-Methyltransferase / genetics
  • Histone-Lysine N-Methyltransferase / pharmacology*
  • Histone-Lysine N-Methyltransferase / physiology
  • Humans
  • Male
  • Molecular Sequence Data
  • Neoplasms / genetics
  • Neoplasms / pathology
  • Nuclear Proteins / chemistry*
  • Nuclear Proteins / genetics
  • Nuclear Proteins / pharmacology*
  • Nuclear Proteins / physiology
  • Peptide Fragments / chemistry
  • Peptide Fragments / pharmacology*
  • Protein Structure, Tertiary / physiology
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • Sequence Homology, Amino Acid
  • Transcription Factors / chemistry*
  • Transcription Factors / genetics
  • Transcription Factors / pharmacology*
  • Transcription Factors / physiology
  • Tumor Cells, Cultured
  • Tumor Suppressor Proteins / chemistry
  • Tumor Suppressor Proteins / genetics
  • Tumor Suppressor Proteins / pharmacology
  • Tumor Suppressor Proteins / physiology

Substances

  • Antineoplastic Agents
  • DNA-Binding Proteins
  • Nuclear Proteins
  • Peptide Fragments
  • RNA, Messenger
  • Transcription Factors
  • Tumor Suppressor Proteins
  • Histone-Lysine N-Methyltransferase
  • PRDM2 protein, human