High-relaxivity MRI contrast agents prepared from miniemulsion polymerization using gadolinium(III)-based metallosurfactants

Pei Gong; Zhengyan Chen; Yingying Chen; Wei Wang; Xiaosong Wang; Aiguo Hu

doi:10.1039/c0cc05746k

High-relaxivity MRI contrast agents prepared from miniemulsion polymerization using gadolinium(III)-based metallosurfactants

Chem Commun (Camb). 2011 Apr 14;47(14):4240-2. doi: 10.1039/c0cc05746k. Epub 2011 Feb 25.

Authors

Pei Gong¹, Zhengyan Chen, Yingying Chen, Wei Wang, Xiaosong Wang, Aiguo Hu

Affiliation

¹ Key Lab for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, 130 Meilong Rd, Shanghai, 200237, China.

PMID: 21359276
DOI: 10.1039/c0cc05746k

Abstract

Miniemulsion polymerization with amphiphilic gadolinium(III) complexes as metallosurfactants was explored as a new technique for the synthesis of high relaxivity MRI contrast agents. Well-defined metallo-colloids with up to 240% enhancement in relaxivity over their small molecular counterparts were obtained.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Contrast Media / chemistry*
Coordination Complexes / chemical synthesis
Coordination Complexes / chemistry
Emulsions / chemistry
Gadolinium / chemistry*
Magnetic Resonance Imaging
Nanostructures / chemistry
Polymerization
Surface-Active Agents / chemistry*

Substances

Contrast Media
Coordination Complexes
Emulsions
Surface-Active Agents
Gadolinium