Potent anti-platelet constituents from Centaurea iberica

Amna Nisar Khan; Itrat Fatima; Urooj Abdul Khaliq; Abdul Malik; Ghulam Abbas Miana; Zia-Ur-Rehman Qureshi; Huma Rasheed

doi:10.3390/molecules16032053

Potent anti-platelet constituents from Centaurea iberica

Molecules. 2011 Feb 28;16(3):2053-64. doi: 10.3390/molecules16032053.

Authors

Amna Nisar Khan¹, Itrat Fatima, Urooj Abdul Khaliq, Abdul Malik, Ghulam Abbas Miana, Zia-Ur-Rehman Qureshi, Huma Rasheed

Affiliation

¹ International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi 75270, Pakistan. abdul.malik@iccs.edu.

Abstract

New naturally occurring nitrogenous compounds 1 and 2, along with a new dimeric lignan glucoside 3, have been isolated from the ethyl acetate soluble fraction of Centaurea iberica. Their structures have been elucidated through spectroscopic techniques. All the isolated compounds showed significant platelet aggregation inhibition.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Centaurea / chemistry*
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy
Platelet Aggregation Inhibitors / chemistry
Platelet Aggregation Inhibitors / isolation & purification*
Platelet Aggregation Inhibitors / pharmacology
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Infrared
Spectrophotometry, Ultraviolet

Substances

Platelet Aggregation Inhibitors