The 2nd Health Econometrics Workshop took place at the Catholic University of Rome in Italy on 15-17 July 2010. The purpose of this meeting was to provide a forum where policy makers, economists and econometricians could discuss the use of statistical and econometric methods to address issues in the field of health economics. There were seven keynote speakers - leading scholars in the subject - invited to give their contributions: Alberto Holly, Stephen Hall, Badi Baltagi, William Greene, Andrew Jones, John Mullahy and Edward Norton. The meeting was attended by 50 participants from around the world, and 17 scientific papers were presented. Some of these works will be published in the forthcoming special issue of Empirical Economics.