Lehualides E-K, cytotoxic metabolites from the Tongan marine sponge Plakortis sp

Jacqueline M Barber; Natelle C H Quek; Dora C Leahy; John H Miller; David S Bellows; Peter T Northcote

doi:10.1021/np100868t

Lehualides E-K, cytotoxic metabolites from the Tongan marine sponge Plakortis sp

J Nat Prod. 2011 Apr 25;74(4):809-15. doi: 10.1021/np100868t. Epub 2011 Feb 25.

Authors

Jacqueline M Barber¹, Natelle C H Quek, Dora C Leahy, John H Miller, David S Bellows, Peter T Northcote

Affiliation

¹ Centre for Biodiscovery and School of Chemical and Physical Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand.

PMID: 21351759
DOI: 10.1021/np100868t

Abstract

Spectroscopy-guided chemical analysis of a marine sponge from the genus Plakortis, collected in Tonga, yielded seven new metabolites of polyketide origin, lehualides E-K (5-11), four of which incorporate various sulfur functionalities. The structures of compounds 5-11 were elucidated by interpretation of spectroscopic data and spectral comparison with model compounds. The biological activities of compounds 6-9 were investigated against human promyeloid leukemic HL-60 cells and two yeast strains, wild-type and a drug-sensitive mutant.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / chemistry
Antineoplastic Agents / isolation & purification*
Antineoplastic Agents / pharmacology*
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
HL-60 Cells
Humans
Marine Biology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Plakortis / chemistry*
Pyrones / chemistry
Pyrones / isolation & purification*
Pyrones / pharmacology*
Saccharomyces cerevisiae / drug effects
Tonga

Substances

Antineoplastic Agents
Pyrones
lehualide F