Abstract
HIV and AIDS remain as the crucial global health concern, therefore, research and development of novel anti-HIV-1 chemical therapeutics is still of paramount significance, which may be illuminated by cases of successful marketed drugs. Herein, we document the discovery and biological profile of new anti-HIV-1 drugs approved by FDA between 2005 and 2008 and some drug candidates are also discussed.
MeSH terms
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Acquired Immunodeficiency Syndrome / drug therapy
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / pharmacology*
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Anti-HIV Agents / therapeutic use
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HIV Fusion Inhibitors / chemistry
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HIV Fusion Inhibitors / pharmacology*
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HIV Fusion Inhibitors / therapeutic use
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HIV Infections / drug therapy
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HIV Integrase Inhibitors / chemistry
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HIV Integrase Inhibitors / pharmacology*
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HIV Integrase Inhibitors / therapeutic use
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HIV Protease Inhibitors / chemistry
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HIV Protease Inhibitors / pharmacology*
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HIV Protease Inhibitors / therapeutic use
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HIV-1 / drug effects*
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Humans
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Molecular Structure
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Reverse Transcriptase Inhibitors / chemistry
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Reverse Transcriptase Inhibitors / pharmacology*
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Reverse Transcriptase Inhibitors / therapeutic use
Substances
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Anti-HIV Agents
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HIV Fusion Inhibitors
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HIV Integrase Inhibitors
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HIV Protease Inhibitors
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Reverse Transcriptase Inhibitors