Isolated ventricular premature beats are the most common arrhythmia in clinical practice. Not all ventricular premature beats are equal, as they may evolve into worsening of the arrhythmia and even severe left ventricular dysfunction in some subsets of patients, particularly those with frequent ventricular premature beats originating from the left ventricle. The resulting systolic dysfunction is reversible following arrhythmia termination. Radiofrequency ablation allows us to achieve effective and safe results and should be considered the treatment of choice. We report a case of left ventricular dysfunction without signs of structural heart disease, secondary to left ventricular premature beats evolved into runs of non-sustained ventricular tachycardia, successfully treated with radiofrequency ablation of the arrhythmic focus.