Association of age with the level of response in the QuantiFERON-TB Gold In-Tube assay for children with active tuberculosis

Roumiana Markova; Rumiana Drenska; Petko Minchev; Yana Todorova; Massimo Ciccozzi; Massimo Amicosante

Association of age with the level of response in the QuantiFERON-TB Gold In-Tube assay for children with active tuberculosis

New Microbiol. 2011 Jan;34(1):81-5. Epub 2011 Jan 15.

Authors

Roumiana Markova¹, Rumiana Drenska, Petko Minchev, Yana Todorova, Massimo Ciccozzi, Massimo Amicosante

Affiliation

¹ Laboratory of Mediators of Inflammation and Immunity, Department of Immunology and Allergology, National Center of Infectious and Parasitic Diseases, Sofia, Bulgaria. markova@ncipd.org

PMID: 21344150

Abstract

QuantiFERON-TB data from 50 children with tuberculosis were analysed to evaluate age related effects. Significantly higher IFN-? responses to TB-specific antigens were associated with younger age, but no difference was found with Mitogen responses. Extrapolating IGRA responses to a Mitogen does not reflect those induced by an antigen-specific stimulus. QFT-IT responses to TB-specific antigens are not compromised with young age.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Age Factors
Antigens, Bacterial / immunology
BCG Vaccine / immunology
Bulgaria
Child
Child, Preschool
Female
Humans
Infant
Interferon-gamma / analysis*
Interferon-gamma / biosynthesis
Male
Mitogens / immunology
Mycobacterium tuberculosis / immunology*
Mycobacterium tuberculosis / physiology
Reagent Kits, Diagnostic / standards*
Tuberculosis / diagnosis*
Tuberculosis / immunology
Tuberculosis / microbiology

Substances

Antigens, Bacterial
BCG Vaccine
Mitogens
Reagent Kits, Diagnostic
Interferon-gamma