Abstract
Two unprecedented cyclic peptides, solomonamides A and B, were isolated from the marine sponge Theonella swinhoei. The structures were elucidated on the basis of comprehensive 1D and 2D NMR analysis and high-resolution mass spectrometry. A combined approach, involving Marfey's method, QM J based analysis, and DFT J/(13)C calculations, was used for establishing the absolute configuration of the entire molecule. Solomonamide A showed in vivo anti-inflammatory activity.
MeSH terms
-
Alanine / chemistry
-
Animals
-
Anti-Inflammatory Agents, Non-Steroidal / chemistry
-
Anti-Inflammatory Agents, Non-Steroidal / isolation & purification*
-
Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
-
Dose-Response Relationship, Drug
-
Edema / drug therapy
-
Marine Biology
-
Mice
-
Molecular Structure
-
Nuclear Magnetic Resonance, Biomolecular
-
Peptides, Cyclic / chemistry
-
Peptides, Cyclic / isolation & purification*
-
Peptides, Cyclic / pharmacology*
-
Serine / chemistry
-
Theonella / chemistry*
Substances
-
Anti-Inflammatory Agents, Non-Steroidal
-
Peptides, Cyclic
-
solomonamide A
-
solomonamide B
-
Serine
-
Alanine