Abstract
Human immunodeficiency virus (HIV) infection causes acquired immune deficiency syndrome (AIDS) and is a global public health issue. Anti-HIV therapy involving chemical drugs has improved the life quality of HIV/AIDS patients. However, emergence of HIV drug resistance, side effects and the necessity for long-term anti-HIV treatment are the main reasons for failure of anti-HIV therapy. Therefore, it is essential to isolate novel anti-HIV therapeutics from natural resources. Recently, a great deal of interest has been expressed regarding marine-derived anti-HIV agents such as phlorotannins, sulfated chitooligosaccharides, sulfated polysaccharides, lectins and bioactive peptides. This contribution presents an overview of anti-HIV therapeutics derived from marine resources and their potential application in HIV therapy.
Keywords:
AIDS; anti-HIV agents; marine resources; phlorotannins.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Anti-HIV Agents / pharmacology*
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Anti-HIV Agents / therapeutic use
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Aquatic Organisms / chemistry*
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Biological Products / chemistry
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Biological Products / pharmacology*
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Biological Products / therapeutic use
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Chitin / analogs & derivatives
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Chitin / chemistry
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Chitin / pharmacology
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Chitin / therapeutic use
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Drug Resistance, Viral
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HIV / drug effects*
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HIV Infections / drug therapy*
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HIV Infections / virology
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Humans
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Lectins / chemistry
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Lectins / pharmacology
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Lectins / therapeutic use
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Oceans and Seas
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Phloroglucinol / analogs & derivatives
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Phloroglucinol / chemistry
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Phloroglucinol / pharmacology
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Phloroglucinol / therapeutic use
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Polysaccharides / chemistry
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Polysaccharides / pharmacology
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Polysaccharides / therapeutic use
Substances
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Anti-HIV Agents
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Biological Products
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Lectins
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Polysaccharides
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Chitin
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Phloroglucinol