Unmanipulated haploidentical peripheral blood stem cell transplantation for precursor T-cell lymphoblastic lymphoma relapsed after autologous PBSCT

J Pediatr Hematol Oncol. 2011 Apr;33(3):224-6. doi: 10.1097/MPH.0b013e31820998f4.

Abstract

Precursor T-cell lymphoblastic lymphoma (T-LBL) is a clinically aggressive disease, associated with a high subsequent relapse rate. We treated a pediatric patient with T-LBL who relapsed after an autologous peripheral blood stem cell transplantation. Unmanipulated peripheral blood was used as a source for the graft. Hematopoietic engraftment was prompt and the risk of graft-versus-host disease was acceptable. The patient has been in continuous complete remission without chronic graft-versus-host disease for 32 months. Hence, haploidentical peripheral blood stem cell transplantation might be one of the adoptive options for salvage therapy in patients with recurrent or refractory T-LBL, and unmanipulated peripheral blood might be acceptable as a graft.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child
  • Graft vs Host Disease / etiology
  • Granulocyte Colony-Stimulating Factor / pharmacology
  • Haplotypes
  • Humans
  • Male
  • Peripheral Blood Stem Cell Transplantation* / adverse effects
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / surgery*
  • Recurrence
  • Transplantation, Autologous

Substances

  • Granulocyte Colony-Stimulating Factor