Frequency, risk factors, and prognosis of prolonged delirium in elderly patients after hip fracture surgery

Clin Orthop Relat Res. 2011 Sep;469(9):2612-20. doi: 10.1007/s11999-011-1806-1. Epub 2011 Feb 15.

Abstract

Background: Delirium in elderly patients after hip fracture surgery is believed to be a transient event, although it frequently lasts for more than 4 weeks.

Questions/purposes: We determined the incidence, risk factors, morbidity, and mortality of prolonged delirium in elderly patients after hip fracture surgery.

Patients and methods: We evaluated 232 elderly patients (older than 65 years) (232 hips) who underwent hip fracture surgery for the development and duration of delirium and categorized them into three groups; nondelirium group, transient (≤ 4 weeks) delirium group, and prolonged (> 4 weeks) delirium group. Patients underwent a global geriatric evaluation, which included postoperative complications, mortality, and functional and mental status evaluations. The three groups were compared with respect to these variables.

Results: Seventy patients (30.2%) had delirium develop, and among these, 14 (20%) had prolonged delirium with a total incidence of 6%. Multivariate analysis showed preinjury dementia was a risk factor of prolonged delirium. At the final followup, five (62.5%) of the eight patients who were ambulatory outdoors in the prolonged delirium group became housebound, whereas only 18 (16.4%) of the 110 patients who were ambulatory outdoors in the nondelirium group became housebound. Survival at 40 months was 81.0% (95% confidence interval, 72.6%-89.3%) in the nondelirium group and 63.6% (95% confidence interval, 35.2%-92.1%) in the prolonged delirium group.

Conclusions: Prolonged delirium was found to be associated with a poor functional outcome and increased mortality.

Level of evidence: Level II, prognostic study. See Guidelines for Authors for a complete description of levels of evidence.

MeSH terms

  • Age Factors
  • Aged
  • Aged, 80 and over
  • Arthroplasty, Replacement, Hip / adverse effects*
  • Arthroplasty, Replacement, Hip / mortality
  • Delirium / diagnosis
  • Delirium / etiology*
  • Delirium / mortality
  • Female
  • Fracture Fixation, Internal / adverse effects*
  • Fracture Fixation, Internal / mortality
  • Hip Fractures / mortality
  • Hip Fractures / surgery*
  • Humans
  • Kaplan-Meier Estimate
  • Logistic Models
  • Male
  • Republic of Korea
  • Risk Assessment
  • Risk Factors
  • Survival Rate
  • Time Factors
  • Treatment Outcome