Myosin drives autophagy in a pathway linking Atg1 to Atg9

EMBO J. 2011 Feb 16;30(4):629-30. doi: 10.1038/emboj.2011.8.

Abstract

The Atg1 kinase promotes autophagy, but its substrates have remained elusive. In this issue of the EMBO Journal, Tang et al identify a myosin light chain kinase as an Atg1 substrate, revealing a pathway that regulates Atg9 trafficking and autophagosome formation.

Publication types

  • Comment

MeSH terms

  • Animals
  • Autophagy / genetics*
  • Autophagy / physiology
  • Autophagy-Related Proteins
  • Humans
  • Membrane Proteins / genetics
  • Membrane Proteins / metabolism
  • Membrane Proteins / physiology*
  • Models, Biological
  • Myosins / genetics
  • Myosins / metabolism
  • Myosins / physiology*
  • Phagosomes / metabolism
  • Phagosomes / physiology
  • Protein Kinases / genetics
  • Protein Kinases / metabolism
  • Protein Kinases / physiology*
  • Protein Transport / physiology
  • Saccharomyces cerevisiae Proteins / genetics
  • Saccharomyces cerevisiae Proteins / metabolism
  • Saccharomyces cerevisiae Proteins / physiology*
  • Signal Transduction / genetics

Substances

  • ATG9 protein, S cerevisiae
  • Autophagy-Related Proteins
  • Membrane Proteins
  • Saccharomyces cerevisiae Proteins
  • Protein Kinases
  • ATG1 protein, S cerevisiae
  • Myosins