Objective: To prepare the nasal thermosensible gels of Chinese medicine Xingbi and study the release mechanism.
Method: The gels were prepared by using P407 as the gel matrix and P188 and PEG 6000 were used to adjust the gelatination temperature. The formulations were screened by the method of orthogonal test. Mathematic models were used to imitate the drug release.
Result: 20% poloxmar 407, 2% poloxmar 188 and 2% PEG 6000 were suitable to Chinese medicine Xingbi thermosensitive gel in situ. Nasal thermosensible gels of Chinese medicine Xingbi was gelated at the temperature between 32-34 degrees C and the dissolution curves in vitro showed that the drug release could be best described by the Higuchi equation.
Conclusion: The formulation of the nasal thermosensible gels of Chinese medicine Xingbi is reasonable and it is worth doing further research.