In vitro and in vivo antioxidant activity of a water-soluble polysaccharide from Dendrobium denneanum

Molecules. 2011 Feb 14;16(2):1579-92. doi: 10.3390/molecules16021579.

Abstract

The water-soluble crude polysaccharide (DDP) obtained from the aqueous extracts of the stem of Dendrobium denneanum through hot water extraction followed by ethanol precipitation, was found to have an average molecular weight (Mw) of about 484.7 kDa. Monosaccharide analysis revealed that DDP was composed of arabinose, xylose, mannose, glucose and galactose in a molar ratio of 1.00:2.66:8.92:34.20:10.16. The investigation of antioxidant activity both in vitro and in vivo showed that DDP is a potential antioxidant.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antioxidants / chemistry
  • Antioxidants / metabolism*
  • Benzothiazoles / chemistry
  • Benzothiazoles / metabolism
  • Dendrobium / anatomy & histology
  • Dendrobium / chemistry*
  • Hydroxyl Radical / chemistry
  • Hydroxyl Radical / metabolism
  • Mice
  • Monosaccharides / analysis
  • Nuclear Magnetic Resonance, Biomolecular
  • Plant Extracts / chemistry
  • Plant Extracts / metabolism
  • Plant Stems / chemistry
  • Polysaccharides / chemistry
  • Polysaccharides / metabolism*
  • Random Allocation
  • Spectroscopy, Fourier Transform Infrared
  • Sulfonic Acids / chemistry
  • Sulfonic Acids / metabolism
  • Superoxide Dismutase / metabolism
  • Water / chemistry*

Substances

  • Antioxidants
  • Benzothiazoles
  • Monosaccharides
  • Plant Extracts
  • Polysaccharides
  • Sulfonic Acids
  • Water
  • 2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid
  • Hydroxyl Radical
  • Superoxide Dismutase