With current therapeutic regimens, asthma should be well controlled in most patients. However, although asthma-related hospital admissions and mortality have decreased, the potential efficacy of treatments is not translating into optimal asthma control and quality of life. This discrepancy may be due to several factors and is complex to analyze. Poor asthma control can be caused by diverse reasons such as the patient's failure to understand how to take the medication, the presence of an untreated, underlying comorbid condition that aggravates the asthma, and the possibility that the patient has a severe form of glucocorticosteroid-insensitive asthma. The present article reviews the situations in which poor asthma control occurs for human-related reasons. These situations can be due to patients themselves and be independent of the disease or can be due to inadequate intervention by health professionals in specific areas and circumstances linked to asthma. A small but important group of patients with asthma is also analyzed; in this group, the asthma per se is severe and is refractory to routine treatments.
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