The first ferrocene analogues of muramyldipeptide

Carbohydr Res. 2011 Apr 1;346(5):678-84. doi: 10.1016/j.carres.2011.01.006. Epub 2011 Jan 15.

Abstract

The two structurally interesting bioorganometallic analogues of muramyldipeptide (MDP) with potential immunomodulatory activity were synthesized starting from the O-protected N-acetylmuramic acid (MurNAc), L- or D-Ala and 1'-aminoferrocene-1-carboxylic acid (Fca). They were fully characterized by IR, (1)H NMR, (13)C NMR and CD spectroscopy as well as by FD mass spectrometry.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carboxylic Acids / chemistry*
  • Circular Dichroism
  • Ferrous Compounds / chemistry*
  • Hydrogen Bonding
  • Magnetic Resonance Spectroscopy
  • Mass Spectrometry
  • Metallocenes
  • Molecular Structure
  • Muramic Acids / chemistry*
  • Peptides / chemical synthesis*
  • Peptides / chemistry*

Substances

  • 1'-aminoferrocene-1-carboxylic acid
  • Carboxylic Acids
  • Ferrous Compounds
  • Metallocenes
  • Muramic Acids
  • Peptides
  • N-acetylmuramic acid
  • ferrocene