Abstract
Chronic fatigue is a common, poorly understood and disabling phenomenon in many diseases. We aim to provide an overview of fatigue in chronic autoimmune and inflammatory disease. Fatigue measurement, prevalence and confounding factors such as depression, sleep disorders and pain are reviewed in the first half of the article. In the second half of the article, we describe explanatory models of fatigue and fatigue signalling, with an emphasis on cytokines and sickness behaviour, oxidative stress, mitochondrial dysfunction and the impact of certain genes on fatigue.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Arthritis, Rheumatoid / epidemiology
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Arthritis, Rheumatoid / physiopathology
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Chronic Disease
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Comorbidity
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Cytokines / metabolism*
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Depression / epidemiology
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Depression / physiopathology
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Disease Models, Animal
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Fatigue / epidemiology*
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Fatigue / genetics
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Fatigue / physiopathology*
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Female
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Genetic Predisposition to Disease / epidemiology*
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Humans
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Male
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Oxidative Stress / physiology*
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Prognosis
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Risk Assessment
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Severity of Illness Index
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Sickness Impact Profile
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Sleep Wake Disorders / epidemiology
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Sleep Wake Disorders / physiopathology