Management of alcoholic liver disease: an update

Alcohol Clin Exp Res. 2011 May;35(5):804-5. doi: 10.1111/j.1530-0277.2010.01402.x. Epub 2011 Feb 1.

Abstract

Treatment of alcoholic liver disease is for the most part based on the stage of the disease and the pathogenic event that is being targeted. The primary treatment modalities that are considered in the treatment of alcoholic liver disease include abstinence, agents that suppress inflammation, anticytokine therapy, nutritional support, modifiers of alcohol metabolism, anti-oxidants, and inhibitors of hepatic fibrosis. Future therapeutic options include exploration of new pathways such as the patatin-like phospholipase domain containing 3 protein (PNPLA-3).

Publication types

  • Review

MeSH terms

  • Alcoholism / genetics
  • Alcoholism / pathology
  • Alcoholism / therapy
  • Animals
  • Anti-Inflammatory Agents / therapeutic use
  • Disease Management
  • Genetic Therapy / trends
  • Humans
  • Lipase / genetics
  • Liver Diseases, Alcoholic / genetics
  • Liver Diseases, Alcoholic / pathology
  • Liver Diseases, Alcoholic / therapy*
  • Membrane Proteins / genetics
  • Nutritional Support / methods
  • Temperance*

Substances

  • Anti-Inflammatory Agents
  • Membrane Proteins
  • Lipase
  • adiponutrin, human