Influenza genome diversity and evolution

Kun-Nan Tsai; Guang-Wu Chen

doi:10.1016/j.micinf.2011.01.013

Influenza genome diversity and evolution

Microbes Infect. 2011 May;13(5):479-88. doi: 10.1016/j.micinf.2011.01.013. Epub 2011 Jan 27.

Authors

Kun-Nan Tsai¹, Guang-Wu Chen

Affiliation

¹ Research Center for Emerging Viral Infections, Chang Gung University, 259 Wen-Hwa 1st Road, Kwei-Shan, Tao-Yuan, Taiwan 333, Taiwan, ROC.

PMID: 21276870
DOI: 10.1016/j.micinf.2011.01.013

Abstract

The influenza viruses contain highly variable genomes and are able to infect a wide range of host species. Large-scale sequencing projects have collected abundant influenza sequence data for assessing influenza genome diversity and evolution. This work reviews current influenza sequence databases characteristics and statistics, as well as recent studies utilizing these databases to unravel influenza virus diversity and evolution. Also discussed are the newest deep sequencing methods and their applications to influenza virus research.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Databases, Genetic
Evolution, Molecular*
Genetic Variation / genetics*
Genome, Viral*
High-Throughput Nucleotide Sequencing
Humans
Influenza A virus / classification
Influenza A virus / genetics*
Influenza A virus / immunology
Phylogeny