Myxomas are rare tumours but are the most common benign tumours of the heart. They can arise from any heart chamber. However, they arise more frequently from the left atrium. They have rarely been described as originating from two different chambers. Their clinical presentation is varied and may mimic arterial embolism or symptoms of cardiac, infectious, malignant and immune diseases, therefore making their diagnosis challenging. We report a case of a young female patient with left atrial and right ventricular myxomas who initially presented with neurological symptoms (visual and speech disturbances). Transoesophageal echocardiography has become an invaluable tool to diagnose myxomas and plan the surgical approach.