Efficient synthesis and biological evaluation of 1,3-benzenedicarbonyl dithioureas

Hao Peng; Yongju Liang; Le Chen; Liwu Fu; Haiqin Wang; Hongwu He

doi:10.1016/j.bmcl.2010.12.130

Efficient synthesis and biological evaluation of 1,3-benzenedicarbonyl dithioureas

Bioorg Med Chem Lett. 2011 Feb 15;21(4):1102-4. doi: 10.1016/j.bmcl.2010.12.130. Epub 2011 Jan 1.

Authors

Hao Peng¹, Yongju Liang, Le Chen, Liwu Fu, Haiqin Wang, Hongwu He

Affiliation

¹ Key Laboratory of Pesticide and Chemical Biology, Ministry of Education, and College of Chemistry, Central China Normal University, Wuhan 430079, PR China.

PMID: 21273072
DOI: 10.1016/j.bmcl.2010.12.130

Abstract

The synthesis and biological activity of 1,3-benzenedicarbonyl dithioureas are described. Bioassay results indicated that these compounds exhibited cytotoxicity against various cancer cells. For example, compounds 4a showed the best inhibition activities against KB and CNE2 with IC(50) 10.72 and 9.91 μM, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / toxicity
Cell Line, Tumor
Humans
Phthalic Acids / chemical synthesis*
Phthalic Acids / chemistry
Phthalic Acids / toxicity
Structure-Activity Relationship
Thiourea / analogs & derivatives*
Thiourea / chemical synthesis
Thiourea / chemistry*
Thiourea / toxicity

Substances

Antineoplastic Agents
Phthalic Acids
Thiourea